PPIRE03879

Target Protein Information
Protein_Name Periplasmic oligopeptide-binding protein OppA
Protein_Sequence MTNITKRSLVAAGVLAALMAGNVALAADVPAGVTLAEKQTLVRNNGSEVQSLDPHKIEGVPESNISRDLFEGLLVSDLDGHPAPGVAESWDNKDAKVWTFHLRKDAKWSDGTPVTAQDFVYSWQRSVDPNTASPYASYLQYGHIAGIDEILEGKKPITDLGVKAIDDHTLEVTLSEPVPYFYKLLVHPSTSPVPKAAIEKFGEKWTQPGNIVTNGAYTLKDWVVNERIVLERSPTYWNNAKTVINQVTYLPIASEVTDVNRYRSGEIDMTNNSMPIELFQKLKKEIPDEVHVDPYLCTYYYEINNQKPPFNDVRVRTALKLGMDRDIIVNKVKAQGNMPAYGYTPPYTDGAKLTQPEWFGWSQEKRNEEAKKLLAEAGYTADKPLTINLLYNTSDLHKKLAIAASSLWKKNIGVNVKLVNQEWKTFLDTRHQGTFDVARAGWCADYNEPTSFLNTMLSNSSMNTAHYKSPAFDSIMAETLKVTDEAQRTALYTKAEQQLDKDSAIVPVYYYVNARLVKPWVGGYTGKDPLDNTYTRNMYIVKH
Organism_Source Escherichia coli (strain K12)
Functional_Classification ATP-binding cassette (ABC) transporter substrate-binding protein (SBP)
Cellular_Localization Extracellular
Gene_Names oppA
UniProt_ID P23843
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name KK
Peptide_Sequence KK
Peptide_Length 2
Peptide_SMILES NCCCC[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 274.36
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 5.50000
Charge_at_pH_7 1.99739
Isoelectric_Point 10.80538
Number_of_Hydrogen_Bond_Acceptors 5
Number_of_Hydrogen_Bond_Donors 5
Topological_Polar_Surface_Area 144.46000
X_logP_energy -0.85890
Interaction Information
Affinity KD=125 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2RKM
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Peptide binding in OppA, the crystal structures of the periplasmic oligopeptide binding protein in the unliganded form and in complex with lysyllysine.
Release_Year 1997
PMID 9245406
DOI 10.1021/bi970457u