PPIRE03884

Target Protein Information
Protein_Name Tyrosine 3-monooxygenase
Protein_Sequence MPTPSASSPQPKGFRRAVSEQDTKQAEAVTSPRFIGRRQSLIEDARKEREAAAAAAAAAVASAEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRALKVFETFEAKIHHLETRPAQRPLAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSAREDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQAYRQRRKLIAEIAFQYKQGEPIPHVEYTKEEIATWKEVYATLKGLYATHACREHLEAFQLLERYCGYREDSIPQLEDVSHFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIRRSLEGVQDELHTLTQALSAIS
Organism_Source Mus musculus
Functional_Classification hydroxylases
Cellular_Localization Cytoplasm
Gene_Names Th
UniProt_ID P24529
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Lysyltyrosine amide
Peptide_Sequence KY
Peptide_Length 2
Peptide_SMILES NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 309.37
Aliphatic_Index 0.00000
Aromaticity 0.50000
Average_Rotatable_Bonds 4.50000
Charge_at_pH_7 0.99684
Isoelectric_Point 9.29830
Number_of_Hydrogen_Bond_Acceptors 5
Number_of_Hydrogen_Bond_Donors 5
Topological_Polar_Surface_Area 138.67000
X_logP_energy -0.03960
Interaction Information
Affinity IC50=490 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Studies on a molecular basis for the heparin-induced regulation of enzymatic activity of mouse striatal tyrosine hydroxylase in vitro. Inhibition of heparin activation and of the enzyme by poly-L-lysyltyrosine and poly-L-lysylphenylalanine and their constituent peptides.
Release_Year 1980
PMID 6109005
DOI 10.1111/j.1471-4159.1980.tb07869.x