PPIRE03996
Target Protein Information
| Protein_Name | Peroxisome proliferator-activated receptor alpha |
|---|---|
| Protein_Sequence | MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSLGEESSGSFSFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPAVPTSTDESPGNALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLAKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVENKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY |
| Organism_Source | Rattus norvegicus |
| Functional_Classification | nuclear hormone receptors |
| Cellular_Localization | Nucleus |
| Gene_Names | Ppara |
| UniProt_ID | P37230 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | H-Trp-Glu-OH |
|---|---|
| Peptide_Sequence | WE |
| Peptide_Length | 2 |
| Peptide_SMILES | N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 333.34 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.50000 |
| Average_Rotatable_Bonds | 4.00000 |
| Charge_at_pH_7 | -1.00024 |
| Isoelectric_Point | 3.84998 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 4 |
| Number_of_Hydrogen_Bond_Donors | 5 |
| Topological_Polar_Surface_Area | 145.51000 |
| X_logP_energy | 0.47190 |
Interaction Information
| Affinity | KD=120 uM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | The dipeptide H-Trp-Glu-OH (WE)shows agonistic activity to peroxisome proliferator-activated protein-Alpha and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells. |
| Release_Year | 2014 |
| PMID | 24821375 |
| DOI | 10.1016/j.bmcl.2014.04.019 |