PPIRE04098
Target Protein Information
| Protein_Name | Peptidyl-prolyl cis-trans isomerase 3 |
|---|---|
| Protein_Sequence | MSRSKVFFDITIGGKASGRIVMELYDDVVPKTAGNFRALCTGENGIGKSGKPLHFKGSKFHRIIPNFMIQGGDFTRGNGTGGESIYGEKFPDENFKEKHTGPGVLSMANAGPNTNGSQFFLCTVKTEWLDGKHVVFGRVVEGLDVVKAVESNGSQSGKPVKDCMIADCGQLKA |
| Organism_Source | Caenorhabditis elegans |
| Functional_Classification | peptidyl-prolyl isomerases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | cyn-3 |
| UniProt_ID | P52011 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Ser-cis-Pro |
|---|---|
| Peptide_Sequence | SP |
| Peptide_Length | 2 |
| Peptide_SMILES | N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 202.21 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 1.50000 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 4 |
| Number_of_Hydrogen_Bond_Donors | 3 |
| Topological_Polar_Surface_Area | 103.86000 |
| X_logP_energy | -1.61840 |
Interaction Information
| Affinity | KD=5.9 mM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Experimental determination of van der waals energies in a biological system. |
| Release_Year | 2007 |
| PMID | 17654646 |
| DOI | 10.1002/anie.200702084 |