PPIRE04154
Target Protein Information
| Protein_Name | Angiotensin-converting enzyme |
|---|---|
| Protein_Sequence | MGQGWAAPGLPRLLLLLLCCGRPLLVPSEGTTGQGTTSQGTTSQVTVNQATTSQATTSNLVSDEAEARKFVEEYDRRSQVVWNEYAEANWNYNTNISTDNSKLLMQKNLQMANHTVKYGTWARRFDVTNFQNATMKRMIKKIQDLERAALPVKELEEYNQILVDMETVYSVASVCHKNGTCLRLEPDLTRLMATSRNYQDLAWAWKSWRDKVGRSILPYFPKYVELTNKAARLNGYQDGGDSWRSMYEMPFLEEELEQLFQELQPLYLNLHAYVRRALHHHYGPDVINLEGPIPAHLLGNMWAQSWSNIYDLVAPFPSAPKMDATEAMIKQGWTPLRMFKEADNFFTSLGLLPMPPEFWNKSMLEKPTDGREVVCHASAWDFFNGKDFRIKQCTSVNMEDLVVAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPTHLHKIGLLSSGDGSYEEDINFLMKMALDKIAFIPFSFLVDQWRWRVFDGSVTRENYNQEWWSLRLKYQGVCPPLARSQDDFDPGAKFHILASVPYVRYFVSFVIQFQFHQALCQAAGHQGPLHKCDIYQSKEAGKLLADAMKLGFSQPWPEAMRLITGQSNMSAASMMTYFKPLLDWLVTENGRHGEKLGWPQYNWTPNSARLEGPVVGSGRVNFLGLDLEEQQARVGQWVLLFLGVALLVATLGLTQRLFSIRHHSLRRPHRGPQFGSEVELRHS |
| Organism_Source | Ovis aries |
| Functional_Classification | dipeptidyl carboxypeptidases |
| Cellular_Localization | Extracellular |
| Gene_Names | ace |
| UniProt_ID | Q4W1E4 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Reduced glutathione |
|---|---|
| Peptide_Sequence | ECG |
| Peptide_Length | 3 |
| Peptide_SMILES | N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 307.32 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | -1.06222 |
| Isoelectric_Point | 3.84996 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 6 |
| Number_of_Hydrogen_Bond_Donors | 6 |
| Topological_Polar_Surface_Area | 158.82000 |
| X_logP_energy | -2.20610 |
Interaction Information
| Affinity | Ki=6.7 uM |
|---|---|
| Affinity_Assay | Lineweaver-Burk analysis (FAPGG hydrolysis) |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Inhibition effect of nicotinamide (vitamin B3)and reduced glutathione (GSH)peptide on angiotensin-converting enzyme activity purified from sheep kidney. |
| Release_Year | 2021 |
| PMID | 34419538 |
| DOI | 10.1016/j.ijbiomac.2021.08.109 |