PPIRE04603
Target Protein Information
| Protein_Name | Minor histocompatibility antigen H13 |
|---|---|
| Protein_Sequence | MDSALSDPHNGSAEAGGPTNSTTRPPSTPEGIALAYGSLLLMALLPIFFGALRSVRCARGKNASDMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLLSMYFFVLGILALSHTISPFMNKFFPASFPNRQYQLLFTQGSGENKEEIINYEFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALAKGEVTEMFSYEESNPKDPAAVTESKEGTEASASKGLEKKEK |
| Organism_Source | Homo sapiens |
| Functional_Classification | intramembrane-cleaving aspartic proteases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | HM13 |
| UniProt_ID | Q8TCT9 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | (Z-LL)2-ketone |
|---|---|
| Peptide_Sequence | XLL |
| Peptide_Length | 3 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN)C(=O)O |
| Chemical_Modification | X1=benzyloxycarbonyl |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Carbobenzyloxy |
| C-terminal_Modification | ketone |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 301.39 |
|---|---|
| Aliphatic_Index | 260.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 4 |
| Number_of_Hydrogen_Bond_Donors | 4 |
| Topological_Polar_Surface_Area | 121.52000 |
| X_logP_energy | 0.09150 |
Interaction Information
| Affinity | IC50=1.33 uM |
|---|---|
| Affinity_Assay | luciferase reporter gene assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals. |
| Release_Year | 2006 |
| PMID | 16697367 |
| DOI | 10.1016/j.ejphar.2006.04.011 |