PPIRE04774
Target Protein Information
| Protein_Name | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
|---|---|
| Protein_Sequence | MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ |
| Organism_Source | Homo sapiens |
| Functional_Classification | transferases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | FNTA |
| UniProt_ID | P49354 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Rap2a CBM peptide |
|---|---|
| Peptide_Sequence | CNIQ |
| Peptide_Length | 4 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CCC(N)=O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 476.55 |
|---|---|
| Aliphatic_Index | 97.50000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.75000 |
| Charge_at_pH_7 | -0.06399 |
| Isoelectric_Point | 5.92254 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 8 |
| Number_of_Hydrogen_Bond_Donors | 8 |
| Topological_Polar_Surface_Area | 236.80000 |
| X_logP_energy | -3.03050 |
Interaction Information
| Affinity | IC50=570 nM |
|---|---|
| Affinity_Assay | scintillation proximity assay |
| PDB_ID | 1TN6 |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Peptide scaffold-derived peptidomimetic farnesyltransferase inhibitors |
| Release_Year | 2021 |
| PMID | None |
| DOI | 10.1002/jccs.202100037 |