PPIRE04837
Target Protein Information
| Protein_Name | Angiotensin-converting enzyme |
|---|---|
| Protein_Sequence | MGAASGRRSPPLLLPLLLLLLPPPPVILELDPALQPGNFPADEAGAQIFAASFNSSAEQVLFQSTAASWAHDTNITEENARLQEEAALLSQEFSEAWGQKAKDLFDPVWQNFTDPTLLRIIGAVRTLGPANLDLEKRQKYNSLLSNMSRIYSTAKVCFPNKTAPCWSLDPELTNILASSRSYTLLLYAWEGWHNAAGIPLKPLYQDFTALSNEAYKQDGFSDTGAYWRSWYDSPTFTEDLERLYQQLEPLYLNLHAYVRRALHRRYGDRYINLRGPIPAHLLGNMWAQSWENIYDTVVPFPDKPNLDVTDVMVQKGWNATHMFRVAEEFFTSLGLLPMPPEFWAESMLEKPSDGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHVQYYLQYKGQHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDQVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNYDWWYLRTKYQGICPPVVRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGHQGPLHQCDIYQSTQAGAKLRALLQAGSSRPWQEVLKDMVGSDNLDARPLLSYFQPVTQWLEEQNQQNGEVLGWPEYQWRPPMPDNYPEGIDLVSDEDEARKFVEEYDRRSQVVWNEYAEANWNYSTDISTDNSKLLMEKNLQMANHTVKYGTWARKFDVTNFQNATMKRMIKKIQDLERAALPTKELEEYNQILLDMETVYSVASVCHENGTCLRLEPDLTNLMATSRNYQDLAWAWKSWRDKVGRSILPYFPKYVELTNKAARLNGYQDGGDSWRSMYEMPFLEEELEQLFQELQPLYLNLHAYVRRALHRHYGPDVINLEGPIPAHLLGNMWAQSWSNIYDLVAPFPSAPKMDATEAMIKQGWTPLRMFKEADNFFTSLGLLPMPPEFWNKSMLEKPTDGREVVCHASAWDFFNGKDFRIKQCTSVNMEDLVVAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPTHLHKINLLSSGDGGYEEDINFLMKMALEKIAFIPFSFLVDQWRWRVFDGSVTRENYNQEWWSLRLKYQGVCPPLARSQDDFDPGAKFHIPASVPYVRYFVSFVIQFQFHQALCQAAGHQGPLHKCDIYQSKEAGKLLADAMKLGFSQPWPEAMRLITGQSNMSAAAMMTYFKPLLDWLVTENGRHGEKLGWPQYNWTPNSARLEGPFVGSGRVNFLGLNLEEQQARVGQWVLLFLGVALLVATLGLTQRLFSIRHHSLRRPHRGPQFGSEVELRHS |
| Organism_Source | Bos taurus |
| Functional_Classification | peptidases |
| Cellular_Localization | Plasma membrane |
| Gene_Names | ACE |
| UniProt_ID | P12820 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Glu-Lys-Gly-Pro |
|---|---|
| Peptide_Sequence | EKGP |
| Peptide_Length | 4 |
| Peptide_SMILES | NCCCC[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 429.47 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.25000 |
| Charge_at_pH_7 | -0.00054 |
| Isoelectric_Point | 6.40880 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 7 |
| Number_of_Hydrogen_Bond_Donors | 6 |
| Topological_Polar_Surface_Area | 205.15000 |
| X_logP_energy | -2.01590 |
Interaction Information
| Affinity | IC50=129.9 mM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Peptide identification in a porcine gelatin prolyl endoproteinase hydrolysate with angiotensin converting enzyme (ACE)inhibitory and hypotensive activity |
| Release_Year | 2017 |
| PMID | None |
| DOI | 10.1016/j.jff.2017.04.018 |