PPIRE05279
Target Protein Information
| Protein_Name | Transporter |
|---|---|
| Protein_Sequence | MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKEHNGVQCLLASQDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVNGQWFLGRGGRVMWTVSSSLSLSTRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLVAQRDVRQFQLRHWLAI |
| Organism_Source | Rattus norvegicus |
| Functional_Classification | neurotransmitter transporters |
| Cellular_Localization | Plasma membrane |
| Gene_Names | Slc6a2 |
| UniProt_ID | A0A0G2KAA8 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | [Dmt1]DALDA |
|---|---|
| Peptide_Sequence | XrFK |
| Peptide_Length | 4 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O |
| Chemical_Modification | X1=2,6-dimethyltyrosine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 506.61 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.25000 |
| Average_Rotatable_Bonds | 4.25000 |
| Charge_at_pH_7 | 1.99769 |
| Isoelectric_Point | 11.65178 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 7 |
| Number_of_Hydrogen_Bond_Donors | 9 |
| Topological_Polar_Surface_Area | 238.54000 |
| X_logP_energy | -1.88093 |
Interaction Information
| Affinity | IC50=3.9 uM |
|---|---|
| Affinity_Assay | cardiac synaptosome uptake assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | A highly potent peptide analgesic that protects against ischemia-reperfusion-induced myocardial stunning. |
| Release_Year | 2002 |
| PMID | 12124228 |
| DOI | 10.1152/ajpheart.00193.2002 |