PPIRE05487
Target Protein Information
| Protein_Name | Gamma-aminobutyric acid receptor-associated protein |
|---|---|
| Protein_Sequence | MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL |
| Organism_Source | Homo sapiens |
| Functional_Classification | ubiquitin-like proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | GABARAP |
| UniProt_ID | O95166 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | BECN1 LIR |
|---|---|
| Peptide_Sequence | FTLIG |
| Peptide_Length | 5 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 549.67 |
|---|---|
| Aliphatic_Index | 156.00000 |
| Aromaticity | 0.20000 |
| Average_Rotatable_Bonds | 3.20000 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 7 |
| Number_of_Hydrogen_Bond_Donors | 7 |
| Topological_Polar_Surface_Area | 199.95000 |
| X_logP_energy | -0.31540 |
Interaction Information
| Affinity | KD=10.5 uM |
|---|---|
| Affinity_Assay | Bio-Layer Interferometry |
| PDB_ID | 6HOI |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs. |
| Release_Year | 2019 |
| PMID | 30767700 |
| DOI | 10.1080/15548627.2019.1581009 |