PPIRE05497
Target Protein Information
| Protein_Name | Nitric oxide synthase 1 |
|---|---|
| Protein_Sequence | MESHMFSVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGQPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTRPLGPPTAAVDLSHQASAGREQTLVVDGATGPGNGPQHAPDPGQEASSLAHANGLAARPPGQDPAKKSTGVALQGSGENNKLLKEIEPVLNLLTSGGKAINGGGPAKTETKDVEIQVDRDLDGKSHKPLPLGVENDRVFSDLWGKGSMPVVLNNPYSEKEQPPASGKQSPTKNGSPSKCPRFLKVKNWETDVVLSDTLHLKSTLGTGCTEHICMGSIMLPSQQIRKPEDVRTKEQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIETTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHIKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSILGDPANVEFTEICIQQGWKPPRSRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDSSRYNILEDVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRNPNSVHEERKYPEPLRFFPRKGPPLSRGDREVHGLAAVRDSQRRSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYVAEAPELTQGLSSVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANQLVKVELLEERNTALGVISNWTDEHRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPSTLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADEVVPCFVRGAPSFHLPQNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMSPCPMVLVFGCRQSKIDHIYREETLQAKSKGVFRELYTAYSREPDKPKKYVQDILQEQLAEPVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQKGKLSVEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS |
| Organism_Source | Bos taurus |
| Functional_Classification | nitric oxide synthases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | NOS1 |
| UniProt_ID | A0A3Q1M6M2 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Ab29-33p |
|---|---|
| Peptide_Sequence | GAEEG |
| Peptide_Length | 5 |
| Peptide_SMILES | C[C@H](NC(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 461.43 |
|---|---|
| Aliphatic_Index | 20.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | -1.99847 |
| Isoelectric_Point | 3.61369 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 8 |
| Number_of_Hydrogen_Bond_Donors | 8 |
| Topological_Polar_Surface_Area | 254.32000 |
| X_logP_energy | -3.65020 |
Interaction Information
| Affinity | KD=131.58 uM |
|---|---|
| Affinity_Assay | fluorescence quenching |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Etiology of Alzheimer's disease: kinetic, thermodynamic and fluorimetric analyses of interactions of pseudo ABeta-peptides with neuronal nitric oxide synthase. |
| Release_Year | 2013 |
| PMID | 24034554 |
| DOI | 10.1016/j.npep.2013.08.001 |