PPIRE05939
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | MEPAPSAGAEQQPALLANASDAYPSAFPSAGTNASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLAIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILVITVCYGLMLLRLRSVRLLSGSKEKDRGLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGRSEPGGFSRGREATARERVTACTPSDGPGVGGAAA |
| Organism_Source | Oryctolagus cuniculus |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | OPRD1 |
| UniProt_ID | G1SEK9 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | DAME |
|---|---|
| Peptide_Sequence | YaGFM |
| Peptide_Length | 5 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 587.69 |
|---|---|
| Aliphatic_Index | 20.00000 |
| Aromaticity | 0.40000 |
| Average_Rotatable_Bonds | 3.20000 |
| Charge_at_pH_7 | -0.00287 |
| Isoelectric_Point | 6.09320 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 8 |
| Number_of_Hydrogen_Bond_Donors | 7 |
| Topological_Polar_Surface_Area | 199.95000 |
| X_logP_energy | -0.06710 |
Interaction Information
| Affinity | IC50=0.2 pM |
|---|---|
| Affinity_Assay | electrical field stimulation bioassay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Effects of the opioid peptides [Met5]enkephalin-Arg6-Phe7 and [Met5]enkephalin-Arg6-Gly7-Leu8 on cholinergic neurotransmission in the rabbit isolated atria. |
| Release_Year | 1987 |
| PMID | 2832111 |
| DOI | 10.1111/j.1440-1681.1987.tb01897.x |