PPIRE06012

Target Protein Information
Protein_Name SPRY domain-containing SOCS box protein 2
Protein_Sequence MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ
Organism_Source Homo sapiens
Functional_Classification SOCS box proteins
Cellular_Localization Cytoplasm
Gene_Names SPSB2
UniProt_ID Q99619
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name M4
Peptide_Sequence DINNN
Peptide_Length 5
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method Main chain-main chain cyclization; D1<->N5; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 588.57
Aliphatic_Index 78.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.80000
Charge_at_pH_7 -1.00157
Isoelectric_Point 3.74999
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 346.29000
X_logP_energy -5.51550
Interaction Information
Affinity KD=465 nM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB)2 and Inducible Nitric Oxide Synthase.
Release_Year 2016
PMID 27214043
DOI 10.1021/acs.jmedchem.6b00386