PPIRE06014

Target Protein Information
Protein_Name Oxytocin receptor
Protein_Sequence MEGTPAANWSVELDLGSGVPPGEEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLGTWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAAEGNDAAGGAGRAALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFFCCSARYLKGSRPGETSVSKKSNSSTFVLSRRSSSQRSCSQPSSA
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Oxtr
UniProt_ID P70536
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name dTOVT
Peptide_Sequence dTOVT
Peptide_Length 5
Peptide_SMILES CC(C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification d(CH2)5, Tyr(Me)2, Orn8
Cyclization_Method Side chain-side chain cyclization; C1<->C6; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 491.50
Aliphatic_Index 58.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.80000
Charge_at_pH_7 -1.00157
Isoelectric_Point 3.74999
Number_of_Hydrogen_Bond_Acceptors 9
Number_of_Hydrogen_Bond_Donors 9
Topological_Polar_Surface_Area 257.48000
X_logP_energy -4.13880
Interaction Information
Affinity Ki=2.19 nM
Affinity_Assay radioligand competition binding assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Comparison of in vitro and in vivo inhibitory effects of peptide and nonpeptide oxytocin antagonists on radioligand binding and uterine contractility of rats during pregnancy.
Release_Year 1996
PMID 8942513
DOI 10.1016/S0002-9378(96)70053-4