PPIRE06128

Target Protein Information
Protein_Name Melanocortin receptor 4
Protein_Sequence MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names MC4R
UniProt_ID P32245
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MBP17
Peptide_Sequence XXRWK
Peptide_Length 5
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X1=1,2-cyclopropane-dicarboxylic acid; X2=D-(2')naphthylalanine
Cyclization_Method Side chain-side chain cyclization; X1<->K5; amide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 602.69
Aliphatic_Index 0.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.80000
Charge_at_pH_7 1.99769
Isoelectric_Point 11.65178
Number_of_Hydrogen_Bond_Acceptors 8
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 283.43000
X_logP_energy -2.28343
Interaction Information
Affinity Ki=0.37 nM
Affinity_Assay competitive radioligand binding assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.
Release_Year 2001
PMID 11606131
DOI 10.1021/jm010165y