PPIRE06145

Target Protein Information
Protein_Name Delta-type opioid receptor
Protein_Sequence MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Oprd1
UniProt_ID P33533
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name [p-I-Phe4]DPDPE
Peptide_Sequence YXGXX
Peptide_Length 5
Peptide_SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O
Chemical_Modification X2=D-penicillamine; X4=p-iodophenylalanine; X5=D-penicillamine
Cyclization_Method Side chain-side chain cyclization; X2<->X5; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 409.40
Aliphatic_Index 0.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 2.20000
Charge_at_pH_7 -0.00287
Isoelectric_Point 6.09320
Number_of_Hydrogen_Bond_Acceptors 7
Number_of_Hydrogen_Bond_Donors 7
Topological_Polar_Surface_Area 199.95000
X_logP_energy -3.18860
Interaction Information
Affinity IC50=1.6 nM
Affinity_Assay radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title A new approach to enhance bioavailability of biologically active peptides: conjugation of a Delte opioid agonist to Beta-cyclodextrin
Release_Year 1993
PMID None
DOI 10.1016/s0960-894x(00)80675-7