PPIRE06166

Target Protein Information
Protein_Name Alpha-glucosidase MAL62
Protein_Sequence MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMRVGEVAHGSDNALYTSAARYEVSEVFSFTHVEVGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFFLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
Organism_Source Saccharomyces cerevisiae
Functional_Classification glycosidases
Cellular_Localization Extracellular
Gene_Names MAL62
UniProt_ID P07265
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name KLPGF
Peptide_Sequence KLPGF
Peptide_Length 5
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 560.69
Aliphatic_Index 78.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.20000
Charge_at_pH_7 0.99769
Isoelectric_Point 9.70000
Number_of_Hydrogen_Bond_Acceptors 7
Number_of_Hydrogen_Bond_Donors 6
Topological_Polar_Surface_Area 196.95000
X_logP_energy -0.10710
Interaction Information
Affinity IC50=59.5 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Anti-diabetic activity peptides from albumin against Alpha-glucosidase and Alpha-amylase.
Release_Year 2012
PMID 22953959
DOI 10.1016/j.foodchem.2012.06.088