PPIRE06175
Target Protein Information
| Protein_Name | N-alpha-acetyltransferase 50 |
|---|---|
| Protein_Sequence | MKGSRIELGDVTPHNIKQLKRLNQVIFPVSYNDKFYKDVLEVGELAKLAYFNDIAVGAVCCRVDHSQNQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEKDGTFDNIYLHVQISNESAIDFYRKFGFEIIETKKNYYKRIEPADAHVLQKNLKVPSGQNADVQKTDN |
| Organism_Source | Homo sapiens |
| Functional_Classification | N-terminal acetyltransferases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | NAA50 |
| UniProt_ID | Q9GZZ1 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | CoA-SASEA |
|---|---|
| Peptide_Sequence | SASEA |
| Peptide_Length | 5 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 463.44 |
|---|---|
| Aliphatic_Index | 40.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.80000 |
| Charge_at_pH_7 | -1.00024 |
| Isoelectric_Point | 3.84998 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 9 |
| Number_of_Hydrogen_Bond_Donors | 9 |
| Topological_Polar_Surface_Area | 257.48000 |
| X_logP_energy | -4.77330 |
Interaction Information
| Affinity | IC50=11 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. |
| Release_Year | 2013 |
| PMID | 23912279 |
| DOI | 10.1038/nsmb.2636 |