PPIRE06220

Target Protein Information
Protein_Name Tyrosine-protein phosphatase non-receptor type 2
Protein_Sequence MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
Organism_Source Homo sapiens
Functional_Classification protein tyrosine phosphatases
Cellular_Localization Cytoplasm
Gene_Names PTPN2
UniProt_ID P17706
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CF-2
Peptide_Sequence DADEXL
Peptide_Length 6
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)O
Chemical_Modification X4=di-fluorophosphonomethylphenylalanine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Carboxyfluorescein
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 618.60
Aliphatic_Index 81.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 3.33333
Charge_at_pH_7 -2.99935
Isoelectric_Point 3.38003
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 320.72000
X_logP_energy -3.66610
Interaction Information
Affinity KD=157.9 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells.
Release_Year 2014
PMID 24387659
DOI 10.1021/cb400903u