PPIRE06245

Target Protein Information
Protein_Name Tyrosine-protein phosphatase non-receptor type 13
Protein_Sequence MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQEVFRRVSIADPAALGFIISPWSLLLLPSGSVSFTDENVSNQDLRASTAPEVLQSHSLTSLADVEKIHIYSLGMTLYWGADHEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSNVKQLVKLVLGNISGTDPLSRSSEQKPDRSQAIRDRLRGKGLPTGRSSTSDALDTHEAPLSQQTFVNKGLSKSMGFLSIRDTRDEEDYLKDTPSDNNSRHEDSETFSSPYQFKTSTPQMDALSKKKTWASSMDLLCAANRDISGETGRYQRCDPKTVTGRTSITPRKKEGRYSDGSIALDIFGPQKVEPVIHTRELPTSTAVSSALDRIRERQQKLQVLREAMNVEEPVRRYKTYHSDIFSISSESPSVISSESDFRQVRKSEASKRFESSSGLPGVDETGQTRPSRQYETSLEGNLINQDIMLRRQEEEMMQLQARMALRQSRLSLYPGDTVKASMLDISRDPLREMALETAMTQRKLRNFFGPEFVKMTVEPFVSLDLPRSILSQTKKGKSEDQRRKVNIRLLSGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATRKENEYFFVDPDLKLTKVAPEGWKEEPKRKGKAAVDFTLFFRIKFFMDDVSLIQHDLTCHQYYLQLRKDLLDERVHCDDEAALLLASLALQAEYGDYQPEVHGVSYFRLEHYLPARVMEKLDVSYIKEELPKLHNTYAGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRALVLRFPWRETKKISFSKKKITLQNTSDGIKHAFQTDSSKACQYLLHLCSSQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTINKLAVRPLSVQAEILKRLSSSEWSLYQPLQNSSKEKTDKASWEEKPRGMSKSYHDLSQASLCPHRKQVINMEALPQAFAELVGKPLYPMARSDTESLAGLPKLDNSKSVASLNRSPERRNHESDSSTEDPGQAYVVGMSLPSSGKSSSQVPFKDNDTLHKRWSIVSSPEREITLVNLKKDPKHGLGFQIIGGEKMGRLDLGVFISAVTPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAVDILQNAPEDVTLVISQPKEKPSKVPSTPVHFANGMKSYTKKPAYMQDSAMDPSEDQPWPRGTLRHIPESPFGLSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDRGWQEPQHSSPSPSVTTKVNEKTFSDSNRSKAKRRGISDLIEHLDCADSDKDDSTYTSSQDHQTSKQEPSSSLSTSNKTSFPTSSASPPKPGDTFEVELAKTDGSLGISVTGGVNTSVRHGGIYVKAIIPKGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQVPTSRERDPAGPQSPPPDQDAQRQAPEKVAKQTPHVKDYSFVTEDNTFEVKLFKNSSGLGFSFSREDNLIPEQINGSIVRVKKLFPGQPAAESGKIDVGDVILKVNGAPLKGLSQQDVISALRGTAPEVSLLLCRPAPGVLPEIDTTFLNPLYSPANSFLNSSKETSQPSSSVEQGASSDDNGVSGKTKNHCRAPSRRESYSDHSESGEDDSVRAPAKMPNVTRVAAFPHEAPRSQEESICAMFYLPRKIPGKLESESSHPPPLDVSPGQTCQPPAECAPSDATGKHFTHLASQLSKEENITTLKNDLGNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQSIGCYVHDVIQDPAKGDGRLKAGDRLIKVNDTDVTNMTHTDAVNLLRAAPKTVRLVLGRILELPRMPVFPHLLPDITVTCHGEELGFSLSGGQGSPHGVVYISDINPRSAAAVDGSLQLLDIIHYVNGVSTQGMTLEDANRALDLSLPSVVLKVTRDGCPVVPTTRAAISAPRFTKANGLTSMEPSGQPALMPKNSFSKVNGEGVHEAVCPAGEGSSSQMKESAGLTETKESNSRDDDIYDDPQEAEVIQSLLDVVDEEAQNLLNQRHATRRACSPDPLRTNGEAPEEGDTDYDGSPLPEDVPESVSSGEGKVDLASLTAASQEEKPIEEDATQESRNSTTETTDGEDSSKDPPFLTNEELAALPVVRVPPSGKYTGTQLQATIRTLQGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDTTRVPLGDEGGYINASFIRIPVGTQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPSILGTTTMANERLRLALLRMQQLKGFIVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIRRSGPVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMVQTEGQYVFCYQVILYVLTHLQAEEQKAQQPGLPQP
Organism_Source Mus musculus
Functional_Classification protein tyrosine phosphatases
Cellular_Localization Cytoplasm
Gene_Names Ptpn13
UniProt_ID Q64512
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name RA-GEF-2 peptide
Peptide_Sequence EQVSAV
Peptide_Length 6
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Dansyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 631.68
Aliphatic_Index 113.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 3.33333
Charge_at_pH_7 -1.00024
Isoelectric_Point 3.84998
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 309.44000
X_logP_energy -3.72320
Interaction Information
Affinity KD=8 uM
Affinity_Assay stopped-flow fluorescence
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Demonstration of long-range interactions in a PDZ domain by NMR, kinetics, and protein engineering.
Release_Year 2006
PMID 17161370
DOI 10.1016/j.str.2006.10.010