PPIRE06276

Target Protein Information
Protein_Name Proteinase-activated receptor 2
Protein_Sequence MRSLSLAWLLGGITLLAASASCNRTVNAPGPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSASVLTGKLTTVFLPVIYIIVFVIGLPSNGMALWVFFFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNDWTYGDALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKRANIAVGVSLAIWLLIFLVTIPLYVMRQTIYIPALNITTCHDVLPEEVLVGDMFSYFLSLAIGVFLFPALLTASAYVLMIKTLRSSAMDEHSEKKRRRAIRLIITVLSMYFICFAPSNVLLVVHYFLIKSQRQSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDQARNALLCRSVRTVKRMQISLTSNKFSRKSSSYSSSSTSVKTSY
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names F2rl1
UniProt_ID Q63645
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FSY-NH2
Peptide_Sequence FSLLRY
Peptide_Length 6
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 797.95
Aliphatic_Index 130.00000
Aromaticity 0.33333
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 0.99713
Isoelectric_Point 9.34881
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 311.18000
X_logP_energy -0.63893
Interaction Information
Affinity IC50=50 uM
Affinity_Assay intracellular calcium fluorescence assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin.
Release_Year 2002
PMID 11805236
DOI 10.1124/jpet.300.2.702