PPIRE06286
Target Protein Information
| Protein_Name | Gap junction alpha-1 protein |
|---|---|
| Protein_Sequence | MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI |
| Organism_Source | Rattus norvegicus |
| Functional_Classification | gap junction proteins |
| Cellular_Localization | Plasma membrane |
| Gene_Names | Gja1 |
| UniProt_ID | P08050 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | AAP10 |
|---|---|
| Peptide_Sequence | GAGXPY |
| Peptide_Length | 6 |
| Peptide_SMILES | C[C@H](NC(=O)CN)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O |
| Chemical_Modification | X4=4-hydroxyproline;Hyp |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 520.54 |
|---|---|
| Aliphatic_Index | 16.66667 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 2.00000 |
| Charge_at_pH_7 | -0.00287 |
| Isoelectric_Point | 6.09320 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 8 |
| Number_of_Hydrogen_Bond_Donors | 7 |
| Topological_Polar_Surface_Area | 220.26000 |
| X_logP_energy | -2.80910 |
Interaction Information
| Affinity | KD=0.41 nM |
|---|---|
| Affinity_Assay | radioligand binding |
| PDB_ID | None |
| Type | Ion channel modulator |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Pharmacological modification of gap junction coupling by an antiarrhythmic peptide via protein kinase C activation. |
| Release_Year | 2002 |
| PMID | 12039852 |
| DOI | 10.1096/fj.01-0918fje |