PPIRE06479

Target Protein Information
Protein_Name C-X-C chemokine receptor type 2
Protein_Sequence MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names CXCR2
UniProt_ID P25025
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 6C6/2
Peptide_Sequence LWDDFW
Peptide_Length 6
Peptide_SMILES CC(C)C[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 880.95
Aliphatic_Index 65.00000
Aromaticity 0.50000
Average_Rotatable_Bonds 3.83333
Charge_at_pH_7 -2.00112
Isoelectric_Point 3.49188
Number_of_Hydrogen_Bond_Acceptors 9
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 315.00000
X_logP_energy 1.50850
Interaction Information
Affinity IC50=16 uM
Affinity_Assay intracellular calcium mobilization assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Identification of biologically active peptides that inhibit binding of human CXCL8 to its receptors from a random phage-epitope library.
Release_Year 2009
PMID 19118103
DOI 10.1189/jlb.0608380