PPIRE06480
Target Protein Information
| Protein_Name | C-X-C chemokine receptor type 2 |
|---|---|
| Protein_Sequence | MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL |
| Organism_Source | Homo sapiens |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | CXCR2 |
| UniProt_ID | P25025 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | 6C6/2 |
|---|---|
| Peptide_Sequence | LWDDFW |
| Peptide_Length | 6 |
| Peptide_SMILES | CC(C)C[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 880.95 |
|---|---|
| Aliphatic_Index | 65.00000 |
| Aromaticity | 0.50000 |
| Average_Rotatable_Bonds | 3.83333 |
| Charge_at_pH_7 | -2.00112 |
| Isoelectric_Point | 3.49188 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 9 |
| Number_of_Hydrogen_Bond_Donors | 11 |
| Topological_Polar_Surface_Area | 315.00000 |
| X_logP_energy | 1.50850 |
Interaction Information
| Affinity | IC50=18 uM |
|---|---|
| Affinity_Assay | chemotaxis assay |
| PDB_ID | None |
| Type | antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Identification of biologically active peptides that inhibit binding of human CXCL8 to its receptors from a random phage-epitope library. |
| Release_Year | 2009 |
| PMID | 19118103 |
| DOI | 10.1189/jlb.0608380 |