PPIRE06489
Target Protein Information
| Protein_Name | fMet-Leu-Phe receptor |
|---|---|
| Protein_Sequence | MDTNMSLLMNKSAVNLMNVSGSTQSVSAGYIVLDVFSYLIFAVTFVLGVLGNGLVIWVAGFRMKHTVTTISYLNLAIADFCFTSTLPFYIASMVMGGHWPFGWFMCKFIYTVIDINLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLAKKVIIVPWICAFLLTLPVIIRLTTVPNSRLGPGKTACTFDFSPWTKDPVEKRKVAVTMLTVRGIIRFIIGFSTPMSIVAICYGLITTKIHRQGLIKSSRPLRVLSFVVAAFFLCWCPFQVVALISTIQVRERLKNMTPGIVTALKITSPLAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERALTEDSAQTSDTGTNLGTNSTSLSENTLNAM |
| Organism_Source | Mus musculus |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | Fpr1 |
| UniProt_ID | P33766 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | fMLFIIK-FITC |
|---|---|
| Peptide_Sequence | MLFIIK |
| Peptide_Length | 6 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)CC |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Formyl |
| C-terminal_Modification | fluorescein isothiocyanate |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 764.04 |
|---|---|
| Aliphatic_Index | 195.00000 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 4.33333 |
| Charge_at_pH_7 | 0.99769 |
| Isoelectric_Point | 9.70000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 9 |
| Number_of_Hydrogen_Bond_Donors | 8 |
| Topological_Polar_Surface_Area | 234.84000 |
| X_logP_energy | 2.08540 |
Interaction Information
| Affinity | KD=2.8 nM |
|---|---|
| Affinity_Assay | saturation binding assay (flow cytometry) |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Functional characterization of three mouse formyl peptide receptors. |
| Release_Year | 2013 |
| PMID | 23160941 |
| DOI | 10.1124/mol.112.081315 |