PPIRE06574
Target Protein Information
| Protein_Name | Activity-regulated cytoskeleton-associated protein |
|---|---|
| Protein_Sequence | MELDHMTTGGLHAYPAPRGGPAAKPNVILQIGKCRAEMLEHVRRTHRHLLTEVSKQVERELKGLHRSVGKLENNLDGYVPTGDSQRWKKSIKACLCRCQETIANLERWVKREMHVWREVFYRLERWADRLESMGGKYPVGSEPARHTVSVGVGGPEPYCQEADGYDYTVSPYAITPPPAAGELPEQESVGAQQYQSWVPGEDGQPSPGVDTQIFEDPREFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLSREAIQRELDLPQKQGEPLDQFLWRKRDLYQTLYVDAEEEEIIQYVVGTLQPKFKRFLRHPLPKTLEQLIQRGMEVQDGLEQAAEPSVTPLPTEDETEALTPALTSESVASDRTQPE |
| Organism_Source | Rattus norvegicus |
| Functional_Classification | synaptic scaffolding proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | Arc |
| UniProt_ID | Q63053 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | TARPg2 peptide |
|---|---|
| Peptide_Sequence | RIPSYR |
| Peptide_Length | 6 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 790.92 |
|---|---|
| Aliphatic_Index | 65.00000 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 3.83333 |
| Charge_at_pH_7 | 1.99713 |
| Isoelectric_Point | 11.14762 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 364.29000 |
| X_logP_energy | -3.15826 |
Interaction Information
| Affinity | KD=60 uM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | 4X3H |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis of arc binding to synaptic proteins: implications for cognitive disease. |
| Release_Year | 2015 |
| PMID | 25864631 |
| DOI | 10.1016/j.neuron.2015.03.030 |