PPIRE06588

Target Protein Information
Protein_Name None
Protein_Sequence MRLNGSAPGPQVAPAGDPLSRPPSGLEAALLAPGFGNSSGNASEPVQAPSSDLDVNTDTYSKVLVTTVYLALFVVGTVGNSVTAFTLARKKSLQNLQGTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAVCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASGLLALPMLFTMGQQNRSADGQHPGGLVCTPIVGTATVKVVIEVNALTSFVIPMAIVSVLNSVIANKLTVMVRQAAEPGPACRAGDPHRSFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHARRLMFCYISDEQWTPFLFDFYHYFYMLSNALFYVSSAINPVLYNLVSASFRQAFLATLACLCPLWGRRRKRPALSRKTNSVSSNHTFSSNVTRETLY
Organism_Source Sus scrofa
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names NTSR1
UniProt_ID A0A287BCE8
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Neuromedin N
Peptide_Sequence RRPYIL
Peptide_Length 6
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 817.00
Aliphatic_Index 130.00000
Aromaticity 0.16667
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 1.99713
Isoelectric_Point 11.14762
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 344.06000
X_logP_energy -1.10446
Interaction Information
Affinity IC50=1.6 nM
Affinity_Assay organ bath isometric smooth muscle contraction assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Neurotensin-related peptides inhibit spontaneous longitudinal contractions of porcine distal jejunum.
Release_Year 1990
PMID 1700398
DOI 10.1016/0196-9781(90)90186-9