PPIRE06607
Target Protein Information
| Protein_Name | Polycomb protein EED |
|---|---|
| Protein_Sequence | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR |
| Organism_Source | Homo sapiens |
| Functional_Classification | WD40 repeat proteins |
| Cellular_Localization | Nucleus |
| Gene_Names | EED |
| UniProt_ID | O75530 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | R26A |
|---|---|
| Peptide_Sequence | SAPATY |
| Peptide_Length | 6 |
| Peptide_SMILES | C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 608.65 |
|---|---|
| Aliphatic_Index | 33.33333 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 2.33333 |
| Charge_at_pH_7 | -0.00287 |
| Isoelectric_Point | 6.09320 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 10 |
| Number_of_Hydrogen_Bond_Donors | 9 |
| Topological_Polar_Surface_Area | 260.72000 |
| X_logP_energy | -3.31030 |
Interaction Information
| Affinity | KD=70 uM |
|---|---|
| Affinity_Assay | fluorescence competition assay |
| PDB_ID | None |
| Type | Allosteric modulator |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Role of the polycomb protein EED in the propagation of repressive histone marks. |
| Release_Year | 2009 |
| PMID | 19767730 |
| DOI | 10.1038/nature08398 |