PPIRE06626

Target Protein Information
Protein_Name AP-2 complex subunit mu
Protein_Sequence MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC
Organism_Source Homo sapiens
Functional_Classification clathrin adaptor proteins
Cellular_Localization Cytoplasm
Gene_Names AP2M1
UniProt_ID Q96CW1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name transferrin receptor peptide
Peptide_Sequence SYTRFS
Peptide_Length 6
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 759.82
Aliphatic_Index 0.00000
Aromaticity 0.33333
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 0.99713
Isoelectric_Point 9.34881
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 351.64000
X_logP_energy -4.35803
Interaction Information
Affinity KD=15 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Selective integrin endocytosis is driven by interactions between the integrin Alpha-chain and AP2.
Release_Year 2016
PMID 26779610
DOI 10.1038/nsmb.3161