PPIRE06630

Target Protein Information
Protein_Name Protein farnesyltransferase subunit beta
Protein_Sequence MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD
Organism_Source Rattus norvegicus
Functional_Classification prenyltransferases
Cellular_Localization Cytoplasm
Gene_Names Fntb
UniProt_ID Q02293
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TKCVIM
Peptide_Sequence TKCVIM
Peptide_Length 6
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCSC)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 693.92
Aliphatic_Index 113.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 3.83333
Charge_at_pH_7 0.93571
Isoelectric_Point 8.54519
Number_of_Hydrogen_Bond_Acceptors 11
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 255.07000
X_logP_energy -1.28290
Interaction Information
Affinity IC50=250 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title The basis for K-Ras4B binding specificity to protein farnesyl-transferase revealed by 2 Angstrom resolution ternary complex structures
Release_Year 2000
PMID 10673434
DOI 10.1016/S0969-2126(00)00096-4