PPIRE06640
Target Protein Information
| Protein_Name | UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase |
|---|---|
| Protein_Sequence | MPSIRLADLAQQLDAELHGDGDIVITGVASMQSAQTGHITFMVNPKYREHLGLCQASAVVMTQDDLPFAKSAALVVKNPYLTYARMAQILDTTPQPAQNIAPSAVIDATAKLGNNVSIGANAVIESGVELGDNVIIGAGCFVGKNSKIGAGSRLWANVTIYHEIQIGQNCLIQSGTVVGADGFGYANDRGNWVKIPQIGRVIIGDRVEIGACTTIDRGALDDTVIGNGVIIDNQCQIAHNVVIGDNTAVAGGVIMAGSLKIGRYCMIGGASVINGHMEICDKVTVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALVMNIDDMSKRLKSLERKVNQQD |
| Organism_Source | Escherichia coli O157:H7 |
| Functional_Classification | acyltransferases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | lpxD |
| UniProt_ID | P65323 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | FITC-RJPXD33(6) |
|---|---|
| Peptide_Sequence | TNLYML |
| Peptide_Length | 6 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Fluorescein Isothiocyanate |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 753.91 |
|---|---|
| Aliphatic_Index | 130.00000 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 3.83333 |
| Charge_at_pH_7 | -0.00287 |
| Isoelectric_Point | 6.09320 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 292.37000 |
| X_logP_energy | -1.12790 |
Interaction Information
| Affinity | KD=22 uM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis. |
| Release_Year | 2014 |
| PMID | 24742680 |
| DOI | 10.1074/jbc.M114.564278 |