PPIRE06654
Target Protein Information
| Protein_Name | Enteropeptidase |
|---|---|
| Protein_Sequence | MGSKRSVPSRHRSLTTYEVMFAVLFVILVALCAGLIAVSWLSIQGSVKDAAFGKSHEARGTLKIISGATYNPHLQDKLSVDFKVLAFDIQQMIDDIFQSSNLKNEYKNSRVLQFENGSIIVIFDLLFDQWVSDKNVKEELIQGIEANKSSQLVTFHIDLNSIDITASLENFSTISPATTSEKLTTSIPLATPGNVSIECPPDSRLCADALKCIAIDLFCDGELNCPDGSDEDNKTCATACDGRFLLTGSSGSFEALHYPKPSNNTSAVCRWIIRVNQGLSIQLNFDYFNTYYADVLNIYEGMGSSKILRASLWSNNPGIIRIFSNQVTATFLIQSDESDYIGFKVTYTAFNSKELNNYEKINCNFEDGFCFWIQDLNDDNEWERTQGSTFPPSTGPTFDHTFGNESGFYISTPTGPGGRRERVGLLTLPLDPTPEQACLSFWYYMYGENVYKLSINISSDQNMEKTIFQKEGNYGQNWNYGQVTLNETVEFKVSFYGFKNQILSDIALDDISLTYGICNVSVYPEPTLVPTPPPELPTDCGGPHDLWEPNTTFTSINFPNSYPNQAFCIWNLNAQKGKNIQLHFQEFDLENIADVVEIRDGEGDDSLFLAVYTGPGPVNDVFSTTNRMTVLFITDNMLAKQGFKANFTTGYGLGIPEPCKEDNFQCKDGECIPLVNLCDGFPHCKDGSDEAHCVRLFNGTTDSSGLVQFRIQSIWHVACAENWTTQISDDVCQLLGLGTGNSSVPTFSTGGGPYVNLNTAPNGSLILTPSQQCLEDSLILLQCNYKSCGKKLVTQEVSPKIVGGSDSREGAWPWVVALYFDDQQVCGASLVSRDWLVSAAHCVYGRNMEPSKWKAVLGLHMASNLTSPQIETRLIDQIVINPHYNKRRKNNDIAMMHLEMKVNYTDYIQPICLPEENQVFPPGRICSIAGWGALIYQGSTADVLQEADVPLLSNEKCQQQMPEYNITENMVCAGYEAGGVDSCQGDSGGPLMCQENNRWLLAGVTSFGYQCALPNRPGVYARVPRFTEWIQSFLH |
| Organism_Source | Bos taurus |
| Functional_Classification | serine proteases |
| Cellular_Localization | Extracellular |
| Gene_Names | TMPRSS15 |
| UniProt_ID | P98072 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Val-(Asp)4-Lys-chloromethane |
|---|---|
| Peptide_Sequence | VDDDDK |
| Peptide_Length | 6 |
| Peptide_SMILES | CC(C)[C@H](N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | chloromethane |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 705.68 |
|---|---|
| Aliphatic_Index | 48.33333 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.00000 |
| Charge_at_pH_7 | -3.00052 |
| Isoelectric_Point | 3.66165 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 12 |
| Number_of_Hydrogen_Bond_Donors | 12 |
| Topological_Polar_Surface_Area | 384.04000 |
| X_logP_energy | -4.49390 |
Interaction Information
| Affinity | Ki=1 mM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | 1EKB |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide. |
| Release_Year | 1999 |
| PMID | 10493881 |
| DOI | 10.1006/jmbi.1999.3089 |