PPIRE06690
Target Protein Information
| Protein_Name | Type-1 angiotensin II receptor |
|---|---|
| Protein_Sequence | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE |
| Organism_Source | Oryctolagus cuniculus |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | AGTR1 |
| UniProt_ID | P34976 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | ANG IV |
|---|---|
| Peptide_Sequence | VYIHPF |
| Peptide_Length | 6 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 774.92 |
|---|---|
| Aliphatic_Index | 113.33333 |
| Aromaticity | 0.33333 |
| Average_Rotatable_Bonds | 3.16667 |
| Charge_at_pH_7 | 0.08804 |
| Isoelectric_Point | 7.54235 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 9 |
| Number_of_Hydrogen_Bond_Donors | 8 |
| Topological_Polar_Surface_Area | 248.94000 |
| X_logP_energy | 1.18740 |
Interaction Information
| Affinity | Ki=1098.7 nM |
|---|---|
| Affinity_Assay | in vitro autoradiography |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Activity of angiotensin peptides in clitoral cavernosum of alloxan induced diabetic rabbit. |
| Release_Year | 2005 |
| PMID | 16084009 |
| DOI | 10.1016/j.eururo.2005.06.017 |