PPIRE06706

Target Protein Information
Protein_Name CHRNA7-FAM7A fusion protein
Protein_Sequence MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Organism_Source Homo sapiens
Functional_Classification nicotinic acetylcholine receptors
Cellular_Localization Plasma membrane
Gene_Names CHRFAM7A
UniProt_ID Q494W8
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name W2R4
Peptide_Sequence WWRRRR
Peptide_Length 6
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1015.19
Aliphatic_Index 0.00000
Aromaticity 0.33333
Average_Rotatable_Bonds 5.16667
Charge_at_pH_7 3.99797
Isoelectric_Point 12.97715
Number_of_Hydrogen_Bond_Acceptors 11
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 488.00000
X_logP_energy -2.67662
Interaction Information
Affinity IC50=1.01 uM
Affinity_Assay calcium imaging
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Oligoarginine Peptides, a New Family of Nicotinic Acetylcholine Receptor Inhibitors.
Release_Year 2019
PMID 31492697
DOI 10.1124/mol.119.117713