PPIRE06726

Target Protein Information
Protein_Name Platelet glycoprotein 4
Protein_Sequence MGCDRNCGLITGAVIGAVLAVFGGILMPVGDLLIEKTIKREVVLEEGTIAFKNWVKTGTTVYRQFWIFDVQNPEEVAKNSSKIKVKQRGPYTYRVRYLAKENITQDPKDSTVSFVQPNGAIFEPSLSVGTENDNFTVLNLAVAAAPHIYTNSFVQGVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSLVPYPISTTVGVFYPYNNTVDGVYKVFNGKDNISKVAIIDTYKGKRNLSYWESYCDMINGTDAASFPPFVEKSQTLRFFSSDICRSIYAVFESEVNLKGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLNPNEDEHRTYLDVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFRNQVTGKIKLLGLVEMVLLGVGVVMFVAFMISYCACRSKNGK
Organism_Source Rattus norvegicus
Functional_Classification scavenger receptors
Cellular_Localization Plasma membrane
Gene_Names Cd36
UniProt_ID Q07969
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 39
Peptide_Sequence XwAWfK
Peptide_Length 6
Peptide_SMILES C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X1=beta-amino-gamma-lactam
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 793.92
Aliphatic_Index 16.66667
Aromaticity 0.50000
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 0.99769
Isoelectric_Point 9.70000
Number_of_Hydrogen_Bond_Acceptors 8
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 266.42000
X_logP_energy 1.29330
Interaction Information
Affinity IC50=10 uM
Affinity_Assay photoaffinity labeling assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides.
Release_Year 2009
PMID 19453183
DOI 10.1021/ja9010628