PPIRE06803

Target Protein Information
Protein_Name Gag polyprotein
Protein_Sequence MGASASVLTGSKLDAWEQIRLKPGSKKKYRLKHLVWASRELERFACNPELLETAEGNEKLLQQLEPALKTGSDSLQSLWNAIVVLWCVHNRYKIGDTQQAIQKLKEVMGSRKSADAAKEDTSARQAGQNYPIVSNAQGQMVHQAISPRTLNAWVKAVEEKAFNPEIIPMFMALSEGAISYDINTMLNAIGGHQGALQVLKEVINEEAVEWDRTHPPPVGPLPPGQIREPTGSDIAGTTSTQQEQIHWTTRPNQPIPVGDIYRKWIVLGLNKMVKMYSPVSILDIKQGPKEPFRDYVDRFYKTLRAEQATQEVKNWMTETLLVQNANPDCKQILKSLGPGATLEEMMVACQGVGGPTHKARVLAEAMATAQQDLKGGYTAVFMQRGQNPIRKGTIKCFNCGKEGHIARNCRAPRKKGCWKCGQEGHQMKDCRNGKQANFLGKYWPPGGTRPGNYVQRPAHPSAPPMEEEVKGQENQEQKGGPNELYPFASLKSLFGTDQ
Organism_Source Human immunodeficiency virus type 1 group O (isolate ANT70)
Functional_Classification matrix protein
Cellular_Localization Cytoplasm
Gene_Names gag
UniProt_ID Q77372
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BCvir
Peptide_Sequence KKQXKL
Peptide_Length 6
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O
Chemical_Modification X4=backbone cyclization building unit
Cyclization_Method main chain-main chain cyclization; N1<->X4; amide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 700.88
Aliphatic_Index 65.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.66667
Charge_at_pH_7 2.99710
Isoelectric_Point 11.10307
Number_of_Hydrogen_Bond_Acceptors 11
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 329.97000
X_logP_energy -2.84770
Interaction Information
Affinity IC50=35 nM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in nondividing cells.
Release_Year 1998
PMID 9548947
DOI 10.1021/bi972878h