PPIRE06808

Target Protein Information
Protein_Name Splicing factor 45
Protein_Sequence MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV
Organism_Source Homo sapiens
Functional_Classification RNA-binding proteins
Cellular_Localization Nucleus
Gene_Names RBM17
UniProt_ID Q96I25
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name peptide 1
Peptide_Sequence KSRWDE
Peptide_Length 6
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method Main chain-side chain cyclization; K1<->E6; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 819.87
Aliphatic_Index 0.00000
Aromaticity 0.16667
Average_Rotatable_Bonds 4.50000
Charge_at_pH_7 -0.00009
Isoelectric_Point 6.49432
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 407.36000
X_logP_energy -3.72963
Interaction Information
Affinity KD=122.3 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM)Domains To Modulate Pre-mRNA Splicing.
Release_Year 2016
PMID 27753493
DOI 10.1021/acs.jmedchem.6b01118