PPIRE06921
Target Protein Information
| Protein_Name | GTPase HRas |
|---|---|
| Protein_Sequence | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS |
| Organism_Source | Homo sapiens |
| Functional_Classification | GTPases |
| Cellular_Localization | Plasma membrane |
| Gene_Names | HRAS |
| UniProt_ID | P01112 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Raf-1 95-101 peptide |
|---|---|
| Peptide_Sequence | CCAVFRL |
| Peptide_Length | 7 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CS)C(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 811.03 |
|---|---|
| Aliphatic_Index | 111.42857 |
| Aromaticity | 0.14286 |
| Average_Rotatable_Bonds | 3.42857 |
| Charge_at_pH_7 | 0.87403 |
| Isoelectric_Point | 8.23141 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 299.82000 |
| X_logP_energy | -1.60533 |
Interaction Information
| Affinity | IC50=7 mM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | In vitro inhibition of Ras-Raf association by short peptides. |
| Release_Year | 1998 |
| PMID | 9636675 |
| DOI | 10.1006/bbrc.1998.8746 |