PPIRE07002

Target Protein Information
Protein_Name Cyclin-A2
Protein_Sequence MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
Organism_Source Homo sapiens
Functional_Classification extracellular matrix proteins
Cellular_Localization Extracellular
Gene_Names CCNA2
UniProt_ID P20248
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CCN1 epitope linear peptide
Peptide_Sequence GLECNFG
Peptide_Length 7
Peptide_SMILES CC(C)C[C@H](NC(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 738.81
Aliphatic_Index 55.71429
Aromaticity 0.14286
Average_Rotatable_Bonds 3.28571
Charge_at_pH_7 -1.06222
Isoelectric_Point 3.84996
Number_of_Hydrogen_Bond_Acceptors 11
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 318.31000
X_logP_energy -3.47130
Interaction Information
Affinity KD=2.1 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 5WTT
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Molecular basis for the recognition of CCN1 by monoclonal antibody 093G9.
Release_Year 2017
PMID 28608634
DOI 10.1002/jmr.2645