PPIRE07030

Target Protein Information
Protein_Name Reticulon-4 receptor
Protein_Sequence MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC
Organism_Source Homo sapiens
Functional_Classification leucine-rich repeat receptors
Cellular_Localization Plasma membrane
Gene_Names RTN4R
UniProt_ID Q9BZR6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NAP2
Peptide_Sequence HIYTALV
Peptide_Length 7
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 815.97
Aliphatic_Index 167.14286
Aromaticity 0.14286
Average_Rotatable_Bonds 3.28571
Charge_at_pH_7 0.08804
Isoelectric_Point 7.54235
Number_of_Hydrogen_Bond_Acceptors 11
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 307.06000
X_logP_energy -0.62990
Interaction Information
Affinity KD=0.45 uM
Affinity_Assay ELISA
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title A novel Nogo-66 receptor antagonist peptide promotes neurite regeneration in vitro.
Release_Year 2016
PMID 26711806
DOI 10.1016/j.mcn.2015.12.011