PPIRE07150

Target Protein Information
Protein_Name C3a anaphylatoxin chemotactic receptor
Protein_Sequence MESSSAETNSTGLHLEPQYQPETILAMAILGLTFVLGLPGNGLVLWVAGLKMRRTVNTVWFLHLTVADFVCCLSLPFSMAHLALRGYWPYGEILCKFIPTVIIFNMFASVFLLTAISLDRCLMVLKPIWCQNHRNVRTACIICGCIWLVAFVLCIPVFVYRETFTLENHTICTYNFSPGSFDYLDYAYDRDAWGYGTPDPIVQLPGEMEHRSDPSSFQTQDGPWSVTTTLYSQTSQRPSEDSFHMDSAKLSGQGKYVDVVLPTNLCGLPMEENRTNTLHNAAFLSSDLDVSNATQKCLSTPEPPQDFWDDLSPFTHEYRTPRLLKVITFTRLVVGFLLPMIIMVACYTLIIFRMRRVRVVKSWNKALHLAMVVVTIFLICWAPYHVFGVLILFINPESRVGAALLSWDHVSIALASANSCFNPFLYALLGRDLRKRVRQSMKGILEAAFSEDISKSTSFIQAKAFSEKHSLSTNV
Organism_Source Cavia porcellus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names C3AR1
UniProt_ID O88680
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PMYPLPR
Peptide_Sequence PMYPLPR
Peptide_Length 7
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 873.08
Aliphatic_Index 55.71429
Aromaticity 0.14286
Average_Rotatable_Bonds 3.14286
Charge_at_pH_7 0.99713
Isoelectric_Point 9.34881
Number_of_Hydrogen_Bond_Acceptors 11
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 288.48000
X_logP_energy -0.24503
Interaction Information
Affinity IC50=790 uM
Affinity_Assay radioreceptor assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Studies on the ileum-contracting mechanisms and identification as a complement C3a receptor agonist of oryzatensin, a bioactive peptide derived from rice albumin.
Release_Year 1996
PMID 8822503
DOI 10.1016/0196-9781(95)02059-4