PPIRE07230
Target Protein Information
| Protein_Name | Translocator protein |
|---|---|
| Protein_Sequence | MPESWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIVWKELGGFTEDAMVPLGLYTGQLALNWAWPPIFFGARQMGWALADLLLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATVLNYYVWRDNSGRRGGSRLPE |
| Organism_Source | Mus musculus |
| Functional_Classification | benzodiazepine receptor |
| Cellular_Localization | Mitochondrion |
| Gene_Names | Tspo |
| UniProt_ID | P50637 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | STHEEHP |
|---|---|
| Peptide_Sequence | STHEEHP |
| Peptide_Length | 7 |
| Peptide_SMILES | C[C@@H](O)[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 835.83 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.42857 |
| Charge_at_pH_7 | -1.81665 |
| Isoelectric_Point | 5.33414 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 14 |
| Number_of_Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 401.55000 |
| X_logP_energy | -5.15240 |
Interaction Information
| Affinity | IC50=140 uM |
|---|---|
| Affinity_Assay | radioligand binding assay |
| PDB_ID | None |
| Type | antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Identification of a peptide antagonist to the peripheral-type benzodiazepine receptor that inhibits hormone-stimulated leydig cell steroid formation. |
| Release_Year | 2002 |
| PMID | 12388644 |
| DOI | 10.1124/jpet.102.039388 |