PPIRE07251

Target Protein Information
Protein_Name AH receptor-interacting protein
Protein_Sequence MADIIARLREDGIQKRVIQEGRGELPDFQDGTKATFHYRTLHSDDEGTVLDDSRARGKPMELIIGKKFKLPVWETIVCTMREGEIAQFLCDIKHVVLYPLVAKSLRNIAVGKDPLEGQRHCCGVAQMREHSSLGHADLDALQQNPQPLIFHMEMLKVESPGTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGHVKEAAAKYYDAIACLKNLQMKEQPGSPEWIQLDQQITPLLLNYCQCKLVVEEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKDEEDKARFRGIFSH
Organism_Source Homo sapiens
Functional_Classification TPR-domain co-chaperones
Cellular_Localization Cytoplasm
Gene_Names AIP
UniProt_ID O00170
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TLEELDW
Peptide_Sequence TLEELDW
Peptide_Length 7
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 904.97
Aliphatic_Index 111.42857
Aromaticity 0.14286
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 -2.99802
Isoelectric_Point 3.42471
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 385.84000
X_logP_energy -1.29160
Interaction Information
Affinity KD=64.5 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal Alpha-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition.
Release_Year 2012
PMID 23300914
DOI 10.1371/journal.pone.0053339