PPIRE07316
Target Protein Information
| Protein_Name | Mu-type opioid receptor |
|---|---|
| Protein_Sequence | YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI |
| Organism_Source | Cavia porcellus |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | OPRM1 |
| UniProt_ID | P97266 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | dermorphin |
|---|---|
| Peptide_Sequence | YaFGYPS |
| Peptide_Length | 7 |
| Peptide_SMILES | C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 803.87 |
|---|---|
| Aliphatic_Index | 14.28571 |
| Aromaticity | 0.42857 |
| Average_Rotatable_Bonds | 2.71429 |
| Charge_at_pH_7 | -0.00372 |
| Isoelectric_Point | 6.08660 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 289.82000 |
| X_logP_energy | -1.40380 |
Interaction Information
| Affinity | IC50=3.3 nM |
|---|---|
| Affinity_Assay | organ bath assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Dermorphins, opioid peptides from amphibian skin, act on opioid receptors of mouse neuroblastoma x rat glioma hybrid cells. |
| Release_Year | 1981 |
| PMID | 6278080 |
| DOI | 10.1111/j.1471-4159.1981.tb06336.x |