PPIRE07351
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | MEPAPSAGAEQQPALLANASDAYPSAFPSAGTNASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLAIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILVITVCYGLMLLRLRSVRLLSGSKEKDRGLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGRSEPGGFSRGREATARERVTACTPSDGPGVGGAAA |
| Organism_Source | Oryctolagus cuniculus |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | OPRD1 |
| UniProt_ID | G1SEK9 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | MEAP |
|---|---|
| Peptide_Sequence | YGGFMRF |
| Peptide_Length | 7 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 877.03 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.42857 |
| Average_Rotatable_Bonds | 3.71429 |
| Charge_at_pH_7 | 0.99713 |
| Isoelectric_Point | 9.34881 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 12 |
| Topological_Polar_Surface_Area | 320.05000 |
| X_logP_energy | -0.98003 |
Interaction Information
| Affinity | IC50=1.4 pM |
|---|---|
| Affinity_Assay | electrical field stimulation bioassay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Effects of the opioid peptides [Met5]enkephalin-Arg6-Phe7 and [Met5]enkephalin-Arg6-Gly7-Leu8 on cholinergic neurotransmission in the rabbit isolated atria. |
| Release_Year | 1987 |
| PMID | 2832111 |
| DOI | 10.1111/j.1440-1681.1987.tb01897.x |