PPIRE07385
Target Protein Information
| Protein_Name | Serine/threonine-protein phosphatase 4 catalytic subunit |
|---|---|
| Protein_Sequence | MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL |
| Organism_Source | Homo sapiens |
| Functional_Classification | protein serine/threonine phosphatases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | PPP4C |
| UniProt_ID | P60510 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | microcystin-LR |
|---|---|
| Peptide_Sequence | aLXRXeX |
| Peptide_Length | 7 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](C)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)O |
| Chemical_Modification | X3=d-erythro-beta-methylaspartic acid; X5=Adda; X7=N-methyldehydroalanine |
| Cyclization_Method | Main chain-main chain cyclization; a1<->X7; amide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 658.71 |
|---|---|
| Aliphatic_Index | 70.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.14286 |
| Charge_at_pH_7 | -0.00024 |
| Isoelectric_Point | 6.41015 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 10 |
| Number_of_Hydrogen_Bond_Donors | 12 |
| Topological_Polar_Surface_Area | 337.12000 |
| X_logP_energy | -4.60463 |
Interaction Information
| Affinity | IC50=0.08 nM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Inhibition of several protein phosphatases by a non-covalently interacting microcystin and a novel cyanobacterial peptide, nostocyclin. |
| Release_Year | 2005 |
| PMID | 16046071 |
| DOI | 10.1016/j.bbagen.2005.06.005 |