PPIRE07483

Target Protein Information
Protein_Name Proteasome subunit beta type-5
Protein_Sequence MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
Organism_Source Homo sapiens
Functional_Classification protease
Cellular_Localization Cytoplasm
Gene_Names PSMB5
UniProt_ID P28074
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name scytonemide A
Peptide_Sequence YGQISVL
Peptide_Length 7
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method Main chain-main chain cyclization; Y1<->L7; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification None
C-terminal_Modification None
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 778.90
Aliphatic_Index 152.85714
Aromaticity 0.14286
Average_Rotatable_Bonds 3.42857
Charge_at_pH_7 -0.00287
Isoelectric_Point 6.09320
Number_of_Hydrogen_Bond_Acceptors 11
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 321.47000
X_logP_energy -2.10720
Interaction Information
Affinity IC50=96 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Scytonemides A and B, cyclic peptides with 20S proteasome inhibitory activity from the cultured cyanobacterium Scytonema hofmanii.
Release_Year 2010
PMID 21058727
DOI 10.1021/np100600z