PPIRE07484

Target Protein Information
Protein_Name None
Protein_Sequence MEPAPSAGAELQPSFLPNASDAYPSTFPSAGANASGPPGTRSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRHDPFVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRSPCGRPEPSSFSRAREATARERVTACTPSDGP
Organism_Source Cavia porcellus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names OPRD1
UniProt_ID A0A286XTF2
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 1a
Peptide_Sequence YxGWXDF
Peptide_Length 7
Peptide_SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification X2=penicillamine; X5=3-trans-mercaptoproline
Cyclization_Method Side chain-side chain cyclization; X2<->X5; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 800.83
Aliphatic_Index 0.00000
Aromaticity 0.42857
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -1.00242
Isoelectric_Point 3.74999
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 311.24000
X_logP_energy -1.40900
Interaction Information
Affinity Ki=4.5 nM
Affinity_Assay radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains.
Release_Year 1995
PMID 24500189
DOI 10.1093/jac/dku010