PPIRE07528
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | MDYILGRYVKIARYGSGGLVGGGGKEQYVEDLALWENIIKTAYCFITPSSYTAALETVNIPEKDFSNCFRFLKENFFIIPSEYNNSTENNRYSRNFLHYQSYGANPVLVQDKLKDAKVVILGCGGIGNHVSVILATSGIGEIILIDNDQIENTNLTRQVLFSENDVGKNKTEVIKRELLKRNSEISVSEIALNINDYTDLHKVPEADIWVVSADHPFNLINWVNKYCVRANQPYINAGYVNDIAVFGPLYVPGKTGCYECQKVVADLYGSEKENIDHKIKLINSRFKPATFAPVNNVAAALCAADVIKFIGKYSEPLSLNKRIGIWSDEIKIHSQNMGRSPVCSVCGNRM |
| Organism_Source | Escherichia coli |
| Functional_Classification | adenylyltransferase |
| Cellular_Localization | Cytoplasm |
| Gene_Names | mccB |
| UniProt_ID | Q2KKH8 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | desformyl MccA |
|---|---|
| Peptide_Sequence | MRTGNAN |
| Peptide_Length | 7 |
| Peptide_SMILES | CSCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 762.84 |
|---|---|
| Aliphatic_Index | 14.28571 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.57143 |
| Charge_at_pH_7 | 0.99798 |
| Isoelectric_Point | 10.55000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 406.23000 |
| X_logP_energy | -6.89363 |
Interaction Information
| Affinity | KD=378.7 uM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor. |
| Release_Year | 2018 |
| PMID | 30881667 |
| DOI | 10.1039/c8sc03173h |