PPIRE07532
Target Protein Information
| Protein_Name | Apolipoprotein A-I |
|---|---|
| Protein_Sequence | MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ |
| Organism_Source | Homo sapiens |
| Functional_Classification | Lipoprotein |
| Cellular_Localization | Extracellular |
| Gene_Names | APOA1 |
| UniProt_ID | P02647 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Kemptide |
|---|---|
| Peptide_Sequence | LRRASLG |
| Peptide_Length | 7 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(C)C)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 771.92 |
|---|---|
| Aliphatic_Index | 125.71429 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.71429 |
| Charge_at_pH_7 | 1.99798 |
| Isoelectric_Point | 12.50011 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 15 |
| Topological_Polar_Surface_Area | 381.95000 |
| X_logP_energy | -4.43056 |
Interaction Information
| Affinity | KD=1000 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Affinity of nonhomologous amphiphilic peptides toward a monoclonal antibody raised against apolipoprotein A-I. |
| Release_Year | 1986 |
| PMID | 3130624 |
| DOI | 10.1002/prot.340010311 |